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Friday, July 10, 2020

Antiphospholipid Antibody Test

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Anti Phospholipid Antibody Test

Antiphospholipid Antibody Test – Antiphospholipid antibodies (APA) are a group of autoantibodies that bind to negatively charged phospholipids. Antiphospholipid antibodies have been associated with thrombotic events which could lead to pregnancy loss, venous and arterial thrombosis, and thrombocytopenia. Antiphospholipid antibodies prevent the blood to flow properly resulting in blood clots causing a health risk to both the mother and the baby. Some important types of phospholipid antibodies are;

  • anticardiolipin
  • antinuclear
  • lupus antibodies

What Is Phospholipid?

A phospholipid is a type of lipid molecule with a phosphate group that forms a major part of the cell membrane. Each Phospholipid constitutes two fatty acids one is the phosphate group and the other is the glycerol molecule. Phospholipid line themselves up in two parallel layers called Phospholipid bilayer and make up the cell membrane. The phospholipid is crucial to the cell’s ability to function.

Antiphospholipid Antibody Syndrome is an autoimmune disorder where the Antiphospholipid Antibodies attack the proteins that aid the binding of phospholipids to the plasma membrane. Antiphospholipid Antibody Syndrome is more common in young women than men.

What Are The Symptoms Of Antiphospholipid Antibody Syndrom?

The common Antiphospholipid Antibody Syndrome symptoms are as follows;

  • Blood clots in the legs
  • Repeated miscarriages or stillbirths
  • Stroke
  • Rash
  • Transitory Ischemic Attack

Few of the less common Antiphospholipid Antibody Syndrome symptoms are;

What Cause Antiphospholipid Antibody Syndrom?

The primary Antiphospholipid Antibody Syndrome cause includes underlying health conditions like an autoimmune disorder, infection, and reaction to certain kinds of medications.

Other risk factors to Antiphospholipid Antibody Syndrome are;

  • Infections like Syphilis, HIV/AIDS, Lyme disease
  • Lupus Erythematosus
  • Genetics

Why Antiphospholipid Antibody Test Advised?

Symptoms concerned with the antiphospholipid antibody are associated with shortness of breath, migraine headaches, deep vein thrombosis, stroke, heart attack, recurrent unexplained venous or arterial blood clots, recurrent unexplained thrombotic episodes, pain and swelling due to the thrombotic episodes, recurrent miscarriages, especially in the 2nd and 3rd trimesters, stillbirth, placental insufficiency, implantation failure, increased rates of IVF failure.

Antiphospholipid Antibodies Test

The antiphospholipid antibody test detects increased levels of various antibodies. The process helps detect any particular set of specimens. It is an essential process in the body’s ability to regulate the clotting of blood. antiphospholipid antibody test helps diagnose the reasons for recurrent miscarriage; asses or monitor a prolonged PTT (partial thromboplastin time) or assess the antiphospholipid antibody syndrome.

Note:

  • Overnight fasting may not be required
  • Doctor’s prescription may be needed
  • The normal reference range may vary depending on gender, age, health history, etc.

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