Friday, March 8, 2019

High Fat Diet May Increase Risk of Heart Disease And Diabetes

Older people who have a high-fat diet packed with omega 6 fatty acids may be at higher risk of developing diabetes, heart failure and a range of other health issues, revealed the latest study. The study, published in the FASEB Journal, investigated the effects of calorie-dense, obesity-generating diet in ageing mice. The findings revealed that the high-fat diet tended to disrupt the composition of the gut microbiome.
The researchers studied how ageing and omega 6-enriched diet impact microflora in the gut, the structure and function of the spleen (abdominal organ), and subsequent immune response to heart attack.

For the study, the team fed an obesity-generating diet to a group of young mice who were able to resolve inflammation after a heart attack, though their gut microflora had already been altered by the diet.

However, when the aged mice were fed a high-fat diet, they were not able to process it well. The heart attack triggered nonresolving inflammation -- associated with heart failure.

"This study highlights that diet and age are critical factors that have the differential impact with age, and it highlights the spleen and heart as an inter-organ communication system with the immune defence system," said Ganesh Halade, Associate Professor at the University of Alabama.

The findings also suggested that obesity-generating diet increased the proportion of neutrophils in the blood of aged mice. You tend to have higher neutrophil count if you have an infection or are under a lot of stress. 

The obesity-generating diet in elderly also led to structural deformities in mice spleens.
Spleen is a secondary immune organ, which happens to be an important component of our body's immunity system. It is a reservoir of disease-fighting leukocytes that move to the heart to begin tissue repair. They also help regulate inflammation in case of heart attack.

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